| Alexander Valley AVA | Anderson Valley AVA | Atlas Peak AVA | Benmore Valley AVA | Bennett Valley AVA | Chalk Hill AVA | Chiles Valley AVA | Clear Lake AVA | Cole Ranch AVA | Covelo AVA | Diamond Mountain District AVA | Dos Rios AVA | Dry Creek | Valley AVA | Green Valley of Russian River Valley AVA | Guenoc Valley AVA | High Valley AVA | Howell Mountain AVA | Knights Valley AVA | Los Carneros AVA | McDowell Valley AVA | Mendocino AVA | Mendocino Ridge AVA | Mt. Veeder AVA | Napa Valley AVA | Northern Sonoma AVA | Oak Knoll District of Napa Valley AVA | Oakville AVA | Potter Valley AVA | Red Hills Lake County AVA | Redwood Valley AVA | Rockpile AVA | Russian River Valley AVA | Rutherford AVA | Solano County Green Valley AVA | Sonoma Coast AVA | Sonoma Mountain AVA | Sonoma Valley AVA | Spring Mountain District AVA | St. Helena AVA | Stags Leap District AVA | Suisun Valley AVA |
- Considered one of the top wine regions in the United States
- Many unique microclimates that have their own AVA designations: Atlas Peak AVA, Calistoga AVA, Chiles Valley AVA, Diamond Mountain District AVA, Howell Mountain AVA, Los Carneros AVA, Mt. Veeder AVA, Oak Knoll District of Napa Valley AVA, Oakville AVA, Rutherford AVA, Spring Mountain District AVA, St. Helena AVA, Stags Leap District AVA, Wild Horse Valley AVA and Yountville AVA
- The valley is home to over 300 wineries and 43,000 acres of vines
- Flanked by the Mayacamas Mountain Range on the western and northern sides and the Vaca Mountains on the eastern side
- Several smaller valleys also exist within these two ranges
- The floor of the main valley gradually rises from sea level at the southern end to 362 feet (110 m) above sea level at the northern end in Calistoga at the foot of Mount Saint Helena
- The soil in the southern end of the valley consists mainly of sediments deposited by earlier advances and retreats of San Pablo Bay
- The soil at the northern end of the valley contains a large volume of volcanic lava and ash
- The open southern end of the valley floor is cooler during the growing season due to the proximity of San Pablo Bay
- The cool wind and fog that is sucked in from San Pablo Bay during the afternoon, cools the vines
- Temperature fluctuations from north to south can vary as much as 15 degrees, even though the valley is only 30 miles long and five miles wide
- The sheltered, closed northern end is often much warmer
- The eastern side of the valley tends to be more arid because winter storms tend to drop much more precipitation on the western mountains and hills